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              垠藝?無聚合物微盲孔載藥(紫杉醇)冠脈支架系統


              產品概述

              垠藝?無聚合物微盲孔載藥(紫杉醇)冠脈支架(以下簡稱"垠藝?支架")是由垠藝生物自主研發、生產的新一代藥物支架,采用創新的載藥理念,為冠狀動脈狹窄患者提供了一種新的治療方案。


              產品特點

              傳統的藥物支架利用高分子聚合物載體攜帶藥物,隨著在臨床上的廣泛使用,已暴露出很多問題,主要表現為:
              內皮愈合延遲引起的晚期支架內血栓
              聚合物慢性刺激和炎癥反應引起的再狹窄晚期追趕現象
              獲得性晚期貼壁不良
              患者因此需要長期服用抗凝血藥物導致的更多出血風險

              目前解決這些問題的有效手段是研發新一代的無聚合物載體藥物支架。

              垠藝?支架采用創新的載藥理念,在金屬表面采用特殊處理工藝構建微米級微盲孔裝載紫杉醇,結合紫杉醇的高度脂溶性特點,使藥物的釋放與抑制細胞增生的效應達到最佳的結合。由于不存在高分子聚合物載體的刺激因素,血管內皮細胞更容易覆蓋支架,實現健康內皮化,縮短患者服用抗凝藥物的時間。

              創新的微盲孔載藥方法
              專利技術實現了微盲孔無聚合物載藥
              微盲孔孔深<500nm,僅為支架厚度1/200
              孔徑1~2μm,大于紫杉醇分子 (<1nm) 千倍以上

              有效的藥物釋放
              微盲孔載藥結合紫杉醇的脂溶性特征,使藥物釋放與抑制細胞增生的效應達到最佳結合。

              • 10天釋放 72%
              • 30天釋放 95%
              • 60天內釋放 100%

              • 60天后 = 100%裸支架

              綠色的天然藥物
              從紅豆杉樹皮和枝葉中天然提取的紫杉醇,是國際上公認的抗腫瘤一線藥物。大量臨床應用顯示,紫杉醇支架在以下方面具有潛在優勢:
              適用于冠心病合并糖尿病引起的血管病變
              適用于雷帕霉素支架引起的支架內再狹窄治療
              適用于雷帕霉素過敏患者

              產品榮譽


              2007年產品獲得SFDA證書,是國內首個無聚合物涂層藥物支架
              2008年產品獲得國家授權發明專利(ZL200610109422.8)
              2008年產品被國家食品藥品監督管理局機關報《中國醫藥報》評為當年度我國醫療器械研發四大亮點,認為是一種具有國際領先水平的藥物支架
              2008年產品被《光明日報》、《科技日報》等國內大型媒體專題介紹
              2009年產品獲得自主創新產品證書
              2011年產品獲得大連市技術發明一等獎
              2012年微盲孔載藥專利獲得遼寧省專利優秀獎

              五分时时彩

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